A detailed analysis of neurons
Examining the functioning of the human body, a universe of sophisticated mechanisms emerges. We often take our skills of movement, thought and perception for granted — but this would not be possible without neurons. A neuron can be defined as “a cell susceptible to electrical impulses, which communicates with other cells through special connections called synapses”. The term synapse may seem complicated, but in reality these are structures that allow a nerve cell to transmit an electrical or chemical signal to another nerve cell.
Many “actions” are as simple as clicking the link in this article. In one thousandth of a second, the body will send and receive thousands of signals (thanks to neurons), to perform the action. Now imagine what would happen if the neurons were damaged or started to deteriorate. It is easy to see that even using a mouse can become complicated or, at worst, impossible.
Unfortunately, inflammation and oxidative stress can seriously destroy or damage neurons and their ability to reprocess electrical impulses. Huntington’s disease, Alzheimer’s and Parkinson’s are all pathologies caused by a deterioration of neurons, which consequently causes a reduction in cognitive and motor functions. These and other conditions share a particular characteristic — they are all neurodegenerative diseases. Protecting neurons is essential, but it is also important to stimulate the body to produce new ones, so as to replace the damaged ones.
The CBD to Improve Memory
Understanding the mechanisms of action of the CBD
You may be wondering what kind of role CBD could play in the development and protection of neurons. Know that you are not the only ones. Many scientists are carefully examining the issue. For better understanding, we begin to analyze the endocannabinoid system (SEC) and the effects of CBD on endocannabinoid production.
CBD interacts with the SEC differently than other cannabinoids. Instead of binding directly to the CB receptors located in the body, the molecule prefers a more indirect approach. But this does not mean that this substance does not affect the CB1 and CB2 receptors.
It appears that the CBD plays a supervisory role for the SEC, ensuring the proper functioning of this system (and promoting homeostasis). A report published in Transitional Psychology points out that CBD supports the production of anandamide (AEA) by blocking its inhibitory enzymes. According to the scientists , precisely endocannabinoids such as AEA could directly intervene in cell signaling in the presence of diseases such as Parkinson’s and Alzheimer’s.
What else does science suggest regarding the link between CBD and neuroprotection?
As we mentioned earlier, one of the mechanisms involved in neuron destruction is oxidative stress. This condition occurs in the event of an imbalance between free radicals and antioxidants. In a study published in the Journal of Neurochemistry , experts try to understand the impact of CBD on oxidative stress, replicating this scenario on cells grown in the laboratory.
The results seem promising, and CBD shows a “combination of neuroprotective, antioxidant and anti-apoptotic effects”. However, it is important to highlight that in vitro studies (outside of a living organism), although useful for determining basic interactions, cannot be compared to experiments on animal guinea pigs or, better yet, to large-scale clinical trials .
Inflammation is another factor that contributes to neurodegeneration. Minimal inflammation levels are essential for stimulating an adequate immune response, but chronic inflammation damages cells or completely destroys them. CBD has been shown to reduce the accumulation of pro-inflammatory cytokines — molecules that contribute to an excessive immune response.
The conclusion? Further studies are needed!
Regardless of whether CBD can affect endocannabinoids or oxidative stress and inflammation, scientists agree that this molecule has potential neuroprotective capabilities. The problem is to precisely determine the mechanism of action of CBD and its possible applications. Unfortunately, with every possible interaction identified, new variables emerge, which take time to be accurately analyzed.
Finally, regardless of the results of scientific research, it is necessary to carry out further investigations before reaching conclusive conclusions. Somewhere, between CBD, SEC, CB receptors and endocannabinoids, the answer to the innumerable unsolved scientific questions could be hidden.